Histone modification governs the cell cycle regulation of a replication Biology Diagrams The expression of histone variants throughout the cell cycle allows them to participate in genome S. B. Variants of core histones and their roles in cell fate decisions, development and cancer Yang, H. D. et al. Oncogenic potential of histone-variant H2A.Z.1 and its regulatory role in cell cycle and epithelial-mesenchymal transition in liver cancer. Oncotarget 7 , 11412-11423 (2016). The acetylation of histones by a number of histone acetyl transferases (HATs) also plays an important role in coordinating gene expression and cell-cycle progression. Components of the cell-cycle regulatory apparatus are both regulated by HATs and bind directly to HATs. Finally transcription factors have been identified as substrate for HATs.
Because histones constitute half of the mass of chromatin, their timely biosynthesis is clearly also a critical event during this phase of the cell cycle. Histones play a crucial role in the packaging of DNA and allow for efficient replication and segregation of chromosomes. For instance, HATs can acetylate histones at specific sites to promote DNA replication and ensure accurate chromosome segregation during mitosis. Furthermore, histone acetylation can regulate the expression of genes involved in cell cycle control, such as cyclins and cyclin-dependent kinases, thereby influencing the progression of the cell cycle. Role of Histone Acetylation in Cell Cycle Regulation Curr Top Med Chem. 2016;16(7):732-44. doi: 10.2174/1568026615666150825140822. Authors Miglena Koprinarova 1 , Michael Schnekenburger, Marc Diederich. Affiliation 1 Institute of Molecular Biology Histones / drug effects*
Variants of core histones and their roles in cell fate decisions ... Biology Diagrams
Histone acetylation is a critical epigenetic modification that changes chromatin architecture and regulates gene expression by opening or closing the chromatin structure. It plays an essential role in cell cycle progression and differentiation. The Download: Download full-size image Fig. 1.. Model depicting the role of histone acetylation in regulation of cellular development. (a).The heterodimerization of cell cycle regulatory factors Max with transcriptional activator Myc supports the formation of multiprotein complex and recruitment of histone acetyltransferase.
